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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q9H3N8: Variant p.Ala138Val

Histamine H4 receptor
Gene: HRH4
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Variant information Variant position: help 138
Type of variant: help LB/B
Residue change: help From Alanine (A) to Valine (V) at position 138 (A138V, p.Ala138Val).
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and hydrophobic (V)
BLOSUM score: help 0
Other resources: help


Sequence information Variant position: help 138
Protein sequence length: help 390
Location on the sequence: help NAVSYRTQHTGVLKIVTLMV A VWVLAFLVNGPMILVSESWK
Residue conservation: help 
Human                         NAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWK

Mouse                         NAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWK

Rat                           NAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWK
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 390 Histamine H4 receptor
Transmembrane 132 – 152 Helical; Name=4
Disulfide bond 87 – 164
Alternative sequence 65 – 152 Missing. In isoform 2.
Helix 132 – 154



Literature citations
Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes.
Oda T.; Morikawa N.; Saito Y.; Masuho Y.; Matsumoto S.;
J. Biol. Chem. 275:36781-36786(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS VAL-138 AND ARG-206;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.