Sequence information
Variant position: 470 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 512 The length of the canonical sequence.
Location on the sequence:
FGMGKRKCIGETIARWEVFL
F LAILLQRVEFSVPLGVKVDM
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FGMGKRKCIGETIARWEVFLF LAILLQRVEFSVPLGVKVDM
FGLGKRKCIGETIARLEVFLF LAILLQQVEFSVPEGTKVDM
Rhesus macaque FGLGKRKCIGETIARWEVFLF LAILLQRVEFSVPPGVKVDM
Mouse FGLGKRKCIGETIGRSEVFLF LAILLQQIEFKVSPGEKVDM
Rat FGLGKRKCIGETIGRLEVFLF LAILLQQMEFNVSPGEKVDM
Rabbit FGLGKRKCIGETIGRLEVFLF LATLLQQVEFSVSPGTTVDM
Sheep FGLGKRQCIGEIIARLEVFLF LAILLHQVEFHVTPGVKVDM
Cat FGLGKRKCIGETIARLEVFLF LAILLQQVEFSVPQGTKVDM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 512
Cytochrome P450 1A1
Metal binding
457 – 457
Iron (heme axial ligand)
Alternative sequence
190 – 512
Missing. In isoform 2.
Alternative sequence
419 – 512
Missing. In isoform 3.
Helix
460 – 477
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.