Sequence information
Variant position: 45 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 635 The length of the canonical sequence.
Location on the sequence:
AEDYLVQGGMSDGLYLLRQS
R NYLGGFALSVAHGRKAHHYT
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AEDYLVQGGMSDGLYLLRQSR NYLGGFALSVAHGRKAHHYT
Mouse AEDYLVQGGMTDGLYLLRQSR NYLGGFALSVAHNRKAHHYT
Rat AEDYLVQGGMTDGLYLLRQSR NYLGGFALSVAHNRKAHHYT
Pig AEDYLVQGGMSDGLYLLRQSR NYLGGFALSVAYDRKAHHYT
Chicken AEEYLMQGGMSDGLYLLRQSR NYLGGFALSLAYGRKVHHYT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 635
Tyrosine-protein kinase SYK
Domain
15 – 107
SH2 1
Modified residue
28 – 28
Phosphotyrosine
Modified residue
44 – 44
Phosphoserine
Modified residue
47 – 47
Phosphotyrosine
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.