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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P08263: Variant p.Thr19Ile

Glutathione S-transferase A1
Gene: GSTA1
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Variant information Variant position: help 19
Type of variant: help LB/B
Residue change: help From Threonine (T) to Isoleucine (I) at position 19 (T19I, p.Thr19Ile).
Physico-chemical properties: help Change from medium size and polar (T) to medium size and hydrophobic (I)
BLOSUM score: help -1
Other resources: help


Sequence information Variant position: help 19
Protein sequence length: help 222
Location on the sequence: help MAEKPKLHYFNARGRMES T RWLLAAAGVEFEEKFIKSAE
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 222 Glutathione S-transferase A1
Initiator methionine 1 – 1 Removed; alternate
Chain 2 – 222 Glutathione S-transferase A1, N-terminally processed
Domain 3 – 83 GST N-terminal
Binding site 9 – 9
Modified residue 1 – 1 N-acetylmethionine
Modified residue 2 – 2 N-acetylalanine; in Glutathione S-transferase A1, N-terminally processed
Modified residue 4 – 4 N6-succinyllysine
Mutagenesis 9 – 9 Y -> F. Decreased isomerase activity.
Helix 17 – 25



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.