Sequence information
Variant position: 425 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 847 The length of the canonical sequence.
Location on the sequence:
YEINQKHLDRIVALFPKDVD
R LRRMSLIEEEGSKRINMAHL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human YEINQKHLDRIVALFPKDVDR LRRMSLIEEEGSKRINMAHL
Mouse YEINQKHLDRIVALFPKDISR MRRMSLIEEEGGKRINMAHL
Rat YEINQKHLDRIVALFPKDIDR MRRMSLIEEEGGKRINMAHL
Bovine YEINQKHLDKIAALFPKDVDR LRRMSLIEEEGGKRINMAHL
Sheep YEINQKHLDKIAALFPKDVDR LRRMSLIEEEGVKRINMAHL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 847
Glycogen phosphorylase, liver form
Helix
423 – 429
Literature citations
Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage.
Newgard C.B.; Nakano K.; Hwang P.K.; Fletterick R.J.;
Proc. Natl. Acad. Sci. U.S.A. 83:8132-8136(1986)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT PRO-425;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.