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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q71U36: Variant p.Glu447Lys

Tubulin alpha-1A chain
Gene: TUBA1A
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Variant information Variant position: help 447
Type of variant: help LB/B
Residue change: help From Glutamate (E) to Lysine (K) at position 447 (E447K, p.Glu447Lys).
Physico-chemical properties: help Change from medium size and acidic (E) to large size and basic (K)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 447
Protein sequence length: help 451
Location on the sequence: help ALEKDYEEVGVDSVEGEGEE E GEEY
Residue conservation: help 
Human                         ALEKDYEEVGVDSVEGEGEEEGEEY

Chimpanzee                    ALEKDYEEVGVDSVEGEGEEEGEEY

Mouse                         ALEKDYEEVGVDSVEGEGEEEGEEY

Rat                           ALEKDYEEVGVDSVEGEGEEEGEEY

Pig                           ALEKDYEEVGVDSVEGEGEEEGEEY

Chicken                       ALEKDYEEVGVDSVEGEGEEEGEEY
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 451 Tubulin alpha-1A chain
Chain 1 – 450 Detyrosinated tubulin alpha-1A chain
Region 432 – 451 Disordered
Site 451 – 451 Involved in polymerization
Modified residue 439 – 439 Phosphoserine
Modified residue 443 – 443 5-glutamyl polyglutamate
Modified residue 445 – 445 5-glutamyl polyglutamate
Modified residue 451 – 451 3'-nitrotyrosine



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.