UniProtKB/SwissProt variant VAR

Nuclear GTPase SLIP-GC
Gene: NUGGC
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Variant information Variant position:

23
Type of variant:

LB/B
Residue change:

From Arginine (R) to Proline (P) at position 23 (R23P, p.Arg23Pro).
Physico-chemical properties:

Change from large size and basic (R) to medium size and hydrophobic (P)
BLOSUM score:

-2
Other resources:

Variant rs6998705 [ dbSNP | Ensembl ]

Sequence information Variant position:

23
Protein sequence length:

796
Location on the sequence:

ETKDVFGQEPHPVEDDLYKE R TRKRRKSDRDQRFRAFPSME
Residue conservation:

Human                         ETKDVFGQEPHPVEDDLYKERTRKRRKSDRDQRFRAFPSME

Mouse                         EMEALVGVVPHSADCDLFKEPVRKRRRLHRDRQFQAFPSAE

Sequence annotation in neighborhood:

Type	Positions	Description
Chain	1 – 796	Nuclear GTPase SLIP-GC
Region	1 – 35	Disordered

Literature citations
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.
Yamada S.; Ohira M.; Horie H.; Ando K.; Takayasu H.; Suzuki Y.; Sugano S.; Hirata T.; Goto T.; Matsunaga T.; Hiyama E.; Hayashi Y.; Ando H.; Suita S.; Kaneko M.; Sasaki F.; Hashizume K.; Ohnuma N.; Nakagawara A.;
Oncogene 23:5901-5911(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS PRO-23; ARG-328 AND ASN-474;

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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q68CJ6: Variant p.Arg23Pro