Sequence information
Variant position: 239 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 691 The length of the canonical sequence.
Location on the sequence:
RAKARARPDNERQKDRGNRE
R DRDSERKKETERKSEGGKEK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human R----AKARARPDNERQKDRGNRER DRDSERKKETERKSEGGKEK
Mouse RNRDGEREKARARAKD-RDRNNRDR DREAERDRERDRRSEG
Rat RNRDGEREKARARAKQDRDRNNKDR DRETERDRDRDRRSDG
Zebrafish KDRDRDKDKSRDREKDKTREKERER EKDRNREKERERDKDR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 691
TRAF3-interacting protein 1
Region
1 – 323
Abolishes microtubules-binding when missing
Region
136 – 508
Disordered
Region
223 – 691
DISC1-interaction domain
Compositional bias
149 – 332
Basic and acidic residues
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.