Sequence information
Variant position: 142 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 213 The length of the canonical sequence.
Location on the sequence:
SSEELQANKATLVCLMNDFY
P GILTVTWKADGTPITQGVEM
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SSEELQANKATLVCLMNDFYP GILTVTWKADGTPITQGVEM
Mouse SLKNLQANKATLVCLVSEFYP GTLVVDWKVDGVPVTQGVET
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
38 – 213
Immunoglobulin lambda-like polypeptide 1
Domain
114 – 208
Ig-like C1-type
Region
109 – 213
C region (By similarity to lambda light-chain)
Disulfide bond
135 – 194
Alternative sequence
70 – 213
FLLQRGSWTGPRCWPRGFQSKHNSVTHVFGSGTQLTVLSQPKATPSVTLFPPSSEELQANKATLVCLMNDFYPGILTVTWKADGTPITQGVEMTTPSKQSNNKYAASSYLSLTPEQWRSRRSYSCQVMHEGSTVEKTVAPAECS -> SAQGHPLGHSVPAVL. In isoform 2.
Beta strand
131 – 143
Literature citations
Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia.
Minegishi Y.; Coustan-Smith E.; Wang Y.H.; Cooper M.D.; Campana D.; Conley M.E.;
J. Exp. Med. 187:71-77(1998)
Cited for: FUNCTION; SUBCELLULAR LOCATION; VARIANT AGM2 LEU-142;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.