Sequence information
Variant position: 300 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2555 The length of the canonical sequence.
Location on the sequence:
NCRCPPEWTGQYCTEDVDEC
Q LMPNACQNGGTCHNTHGGYN
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NCRCPPEWTGQYCTEDVDECQ LMPNACQNGGTCHNTHGGYN
Mouse NCRCPPEWTGQYCTEDVDECQ LMPNACQNGGTCHNTHGGYN
Rat NCRCPPEWTGQYCTEDVDECQ LMPNACQNGGTCHNSHGGYN
Xenopus laevis NCQCPPDWTGQYCTEDVDECQ LMPNACQNGGTCHNTYGGYN
Xenopus tropicalis NCQCPPDWTGQYCTEDVDECQ LMPNACQNGGTCHNTYGGYN
Zebrafish NCHCDKHWTGQYCTEDVDECE LSPNACQNGGTCHNTIGGFH
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
19 – 2555
Neurogenic locus notch homolog protein 1
Topological domain
19 – 1735
Extracellular
Domain
295 – 333
EGF-like 8; calcium-binding
Glycosylation
311 – 311
O-linked (Fuc...) threonine
Disulfide bond
299 – 312
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.