Variant position: 163 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 213 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DGQPIFAN---ITLPVYTLKERC LQVV-----RSLVKPENY-RRLDIVRS
Mouse DGQPIFAN---ITLPVYTLKERC LQVV-----RSLVKPENY
Rat DGQPIFAN---ITLPVYTLKERC LQVV-----RSLVKPENY
Caenorhabditis elegans RMNLIVRNHCVITMKVQSLREIA GRSFLRH--NPTEVPNKI
Drosophila DQLVDVRSEVLIHFPMRSLRENC LWLVARWLIRTSNAPRRI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 213 von Hippel-Lindau disease tumor suppressor
157 – 166 Interaction with Elongin BC complex
158 – 169
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-67 AND 156-213; VARIANT PRO-163;
Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel-Lindau gene in a renal cell carcinoma.
Wiesener M.S.; Seyfarth M.; Warnecke C.; Juergensen J.S.; Rosenberger C.; Morgan N.V.; Maher E.R.; Frei U.; Eckardt K.-U.;
Cited for: VARIANT RCC PRO-163; CHARACTERIZATION OF VARIANT RCC PRO-163;
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