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UniProtKB/Swiss-Prot P04637: Variant p.Arg337His

Cellular tumor antigen p53
Gene: TP53
Variant information

Variant position:  337
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LP/P [Disclaimer]
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Arginine (R) to Histidine (H) at position 337 (R337H, p.Arg337His).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and basic (R) to medium size and polar (H)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  0
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In LFS; germline mutation and in sporadic cancers; somatic mutation.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  337
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  393
The length of the canonical sequence.

Location on the sequence:   QPKKKPLDGEYFTLQIRGRE  R FEMFRELNEALELKDAQAGK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         QPK----KK----PLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGK

                              PQK----KK----PLDGEYFTLQIRGRERYEMFRNLNEALE

Rhesus macaque                QPK----KK----PLDGEYFTLQIRGRERFEMFRELNEALE

Mouse                         PQK----KK----PLDGEYFTLKIRGRKRFEMFRELNEALE

Rat                           QQK----KK----PLDGEYFTLKIRGRERFEMFRELNEALE

Pig                           VQK----KK----PLDGEYFTLQIRGRERFEMFRELNDALE

Bovine                        QPK----KK----PLDGEYFTLQIRGFKRYEMFRELNDALE

Rabbit                        QTK----KK----PLDGEYFILKIRGRERFEMFRELNEALE

Sheep                         QQK----KK----PLDGEYFTLQIRGRKRFEMFRELNEALE

Cat                           PQK----KK----PLDGEYFTLQIRGRERFEMFRELNEALE

Chicken                       PPK----KR--VLNPDNEIFYLQVRGRRRYEMLKEINEALQ

Xenopus laevis                LPK----KRLVVVDDDEEIFTLRIKGRSRYEMIKKLNDALE

Zebrafish                     RPEGSKKAK--GSSSDEEIFTLQVRGRERYEILKKLNDSLE

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
Region 100 – 370 Interaction with HIPK1
Region 300 – 393 Interaction with CARM1
Region 319 – 360 Interaction with HIPK2
Region 325 – 356 Oligomerization
Modified residue 321 – 321 N6-acetyllysine
Modified residue 333 – 333 Omega-N-methylarginine; by PRMT5
Modified residue 335 – 335 Symmetric dimethylarginine; by PRMT5
Modified residue 337 – 337 Symmetric dimethylarginine; by PRMT5
Alternative sequence 332 – 346 IRGRERFEMFRELNE -> MLLDLRWCYFLINSS. In isoform 3, isoform 6 and isoform 9.
Alternative sequence 332 – 341 IRGRERFEMF -> DQTSFQKENC. In isoform 2, isoform 5 and isoform 8.
Mutagenesis 319 – 319 K -> A. Loss of nuclear localization; when associated with A-320 and A-321.
Mutagenesis 320 – 320 K -> A. Loss of nuclear localization; when associated with A-319 and A-321.
Mutagenesis 321 – 321 K -> A. Loss of nuclear localization; when associated with A-319 and A-320.
Mutagenesis 333 – 337 RGRER -> KGKEK. Reduced methylation by PRMT5. Reduced nuclear localization. Decreased binding to promoters of target genes. Reduced transcriptional activity. Decrease in cell cycle arrest.
Helix 335 – 354


Literature citations

An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma.
Ribeiro R.C.; Sandrini F.; Figueiredo B.; Zambetti G.P.; Michalkiewicz E.; Lafferty A.R.; DeLacerda L.; Rabin M.; Cadwell C.; Sampaio G.; Cat I.; Stratakis C.A.; Sandrini R.;
Proc. Natl. Acad. Sci. U.S.A. 98:9330-9335(2001)
Cited for: VARIANT ADCC HIS-337;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.