Variant position: 337 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QPK----KK----PLDGEYFTLQIRGRE RFEMFRELNEALELKDAQAGK
Rhesus macaque QPK----KK----PLDGEYFTLQIRGRE RFEMFRELNEALE
Mouse PQK----KK----PLDGEYFTLKIRGRK RFEMFRELNEALE
Rat QQK----KK----PLDGEYFTLKIRGRE RFEMFRELNEALE
Pig VQK----KK----PLDGEYFTLQIRGRE RFEMFRELNDALE
Bovine QPK----KK----PLDGEYFTLQIRGFK RYEMFRELNDALE
Rabbit QTK----KK----PLDGEYFILKIRGRE RFEMFRELNEALE
Sheep QQK----KK----PLDGEYFTLQIRGRK RFEMFRELNEALE
Cat PQK----KK----PLDGEYFTLQIRGRE RFEMFRELNEALE
Chicken PPK----KR--VLNPDNEIFYLQVRGRR RYEMLKEINEALQ
Xenopus laevis LPK----KRLVVVDDDEEIFTLRIKGRS RYEMIKKLNDALE
Zebrafish RPEGSKKAK--GSSSDEEIFTLQVRGRE RYEILKKLNDSLE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 393 Cellular tumor antigen p53
100 – 370 Interaction with HIPK1
300 – 393 Interaction with CARM1
319 – 360 Interaction with HIPK2
325 – 356 Oligomerization
321 – 321 N6-acetyllysine
332 – 346 IRGRERFEMFRELNE -> MLLDLRWCYFLINSS. In isoform 3, isoform 6 and isoform 9.
332 – 341 IRGRERFEMF -> DQTSFQKENC. In isoform 2, isoform 5 and isoform 8.
319 – 319 K -> A. Loss of nuclear localization; when associated with A-320 and A-321.
320 – 320 K -> A. Loss of nuclear localization; when associated with A-319 and A-321.
321 – 321 K -> A. Loss of nuclear localization; when associated with A-319 and A-320.
335 – 354
An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma.
Ribeiro R.C.; Sandrini F.; Figueiredo B.; Zambetti G.P.; Michalkiewicz E.; Lafferty A.R.; DeLacerda L.; Rabin M.; Cadwell C.; Sampaio G.; Cat I.; Stratakis C.A.; Sandrini R.;
Proc. Natl. Acad. Sci. U.S.A. 98:9330-9335(2001)
Cited for: VARIANT ADCC HIS-337;
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