Variant position: 560 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 662 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HASVHLGQLDWYSWVPNAPC TMRLPPPTTKDATLETVMATL
Mouse HSSIHLGQLDWFYWVPNAPC TMRLPPPKTKDATMEKLMATL
Rat HSSVHLGQLDWFYWVPNAPC TMRLPPPTTKEATMEKLMATL
Pig HSSNHLGQLDWYSWVPNAPC TMRLPPPTTKDATLETVMATL
Bovine HSSTHLGQLDWYSWVPNAPC TMRLPPPTTKDVTLEKVMATL
Rabbit HSSIHLGQLDWFTWVPNAPC TMRLPPPTTKDATLETVMATL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 662 Arachidonate 15-lipoxygenase
115 – 662 Lipoxygenase
540 – 540 Iron; catalytic
544 – 544 Iron; catalytic
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.
Assimes T.L.; Knowles J.W.; Priest J.R.; Basu A.; Borchert A.; Volcik K.A.; Grove M.L.; Tabor H.K.; Southwick A.; Tabibiazar R.; Sidney S.; Boerwinkle E.; Go A.S.; Iribarren C.; Hlatky M.A.; Fortmann S.P.; Myers R.M.; Kuhn H.; Risch N.; Quertermous T.;
Cited for: VARIANT MET-560; CHARACTERIZATION OF VARIANT MET-560; INVOLVEMENT IN CORONARY ARTERY DISEASE;
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