Variant position: 244 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 284 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DYSMVRFLPYDQSDEESMNI VLQHIDFAIQYGEDLEFKEPK--
Mouse DYSMVRFLPYDQSDEESMNI VLQHIDFAIQYGEDLEFKEPR
Rat DYSMVRFLPYDQSDEESMNI VLQHIDFAIQYGEDLEFKEPK
Bovine DYSMVRFLPYDQSDEESMNI VLQHIDFAIQYGEDLEFKEPK
Xenopus laevis DYSMVRFLPFDRSDEECMNI VLQHIDFAIQYGEDLEFKEPR
Xenopus tropicalis DYSMVRFLPFDRSDEECMNI VLQHIDFAIQYGEDLEFKEPK
Zebrafish DYSMVRFLPFDRTDEEGINI VLQHIDFSIQYGEDLEVKEPK
Slime mold DFSLVGFVPLDITDQESLNV LLQHIDNSIQYGEDLEPKEPP
Baker's yeast DFGMVQFLPLESNNPDSIET ILSYVDDITQWAEGQEQKEPN
Fission yeast DFNMVNFLPLESGNEESVSR VLSYIDDATQWYEDQEPKDPD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 284 GPN-loop GTPase 3
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS VAL-52 AND ALA-244;
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