Variant position: 117 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1782 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QEEEEVIVTEVGQRDSEDVS KRDSDKEMATKSAVVHDITDD
Mouse --EEEVTVEDVGQRESEDVK EKDRAKEMAASSTVVEDITKD
Rat --EEEVVDEDVGQRESEDVR EKDRVEEMAANSTAVEDITKD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 1782 A-kinase anchor protein 12
106 – 106 E -> M. In isoform 3.
Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein.
Nauert J.B.; Klauck T.M.; Langeberg L.K.; Scott J.D.;
Curr. Biol. 7:52-62(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS GLU-117; GLN-216 AND SER-987;
Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method.
Nakajima D.; Saito K.; Yamakawa H.; Kikuno R.F.; Nakayama M.; Ohara R.; Okazaki N.; Koga H.; Nagase T.; Ohara O.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS GLU-117; GLN-216 AND ASP-1600;
Sequence of gravin cDNA isolated from a human umbilical vein endothelial cell library.
Bowditch R.D.; Ginsberg M.H.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-1782; VARIANTS GLU-117 AND GLN-216;
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Bian Y.; Song C.; Cheng K.; Dong M.; Wang F.; Huang J.; Sun D.; Wang L.; Ye M.; Zou H.;
J. Proteomics 96:253-262(2014)
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154; SER-483; SER-598; SER-612; SER-627; SER-696; SER-697; SER-698; SER-761; SER-1328; SER-1395 AND SER-1587; VARIANT [LARGE SCALE ANALYSIS] GLU-117; IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];
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