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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q8ND04: Variant p.Pro280Leu

Nonsense-mediated mRNA decay factor SMG8
Gene: SMG8
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Variant information Variant position: help 280
Type of variant: help LB/B
Residue change: help From Proline (P) to Leucine (L) at position 280 (P280L, p.Pro280Leu).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help -3
Other resources: help


Sequence information Variant position: help 280
Protein sequence length: help 991
Location on the sequence: help PCPPRLLFLFQLNGALKVEP P RNQDPAHPDKPKKHSPKRRL
Residue conservation: help 
Human                         PCPPRLLFLFQLNGALKVEPPRNQDPAHPDKPKKHSPKRRL

Mouse                         PCPPRLLFLFQLNGALKVEPPRSQDTAHPDKPKKHSPKRRL

Bovine                        PCPPRLLFLFQLNGALKVEPPRNQDPAHPDKPKKHSPKRRL

Xenopus tropicalis            PCPPRLLFIFQLNGALKVE-PKSQGPQTNEKPKKHSPKRRL

Caenorhabditis elegans        MVVPRLLIAFQRNNI--------RPDVNPGKKLQRELYEKL

Drosophila                    LCTPRILFLFE--------------NFPSDEPKTRECVSTY
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 991 Nonsense-mediated mRNA decay factor SMG8
Region 279 – 299 Disordered
Compositional bias 279 – 289 Basic and acidic residues



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.