Sequence information
Variant position: 75 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1270 The length of the canonical sequence.
Location on the sequence:
VVDYETDPAVVTGENISLSL
Q GVEVFGHEKSSSDFISKQVL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VVDYETDPAVVTGENISLSLQ GVEVFGHEKSSSDFISKQVL
Mouse VVDYEMDPAVDSSESVSLSHQ CVEELAYPEPSSDFMGKHEF
Rat --------------------- --------------------
Bovine --------------------- --------------------
Xenopus laevis ILDQQSDNEINKHYLLQSPNA LELDSTLDYIGNAAGHCDTF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 1270
Microtubule-associated tumor suppressor 1
Alternative sequence
1 – 928
Missing. In isoform 4.
Alternative sequence
1 – 855
Missing. In isoform 7.
Alternative sequence
1 – 834
Missing. In isoform 3.
Alternative sequence
1 – 753
Missing. In isoform 6.
Literature citations
Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma.
Di Benedetto M.; Pineau P.; Nouet S.; Berhouet S.; Seitz I.; Louis S.; Dejean A.; Couraud P.-O.; Strosberg A.D.; Stoppa-Lyonnet D.; Nahmias C.;
Mol. Cell. Endocrinol. 252:207-215(2006)
Cited for: VARIANTS HCC LYS-75; SER-563; HIS-873 AND ARG-1201; VARIANTS ARG-148; MET-425; THR-453; ARG-575; THR-911 AND GLN-1105;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.