Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q9H790: Variant p.Gly172Val

Exonuclease V
Gene: EXO5
Feedback?
Variant information Variant position: help 172
Type of variant: help LB/B
Residue change: help From Glycine (G) to Valine (V) at position 172 (G172V, p.Gly172Val).
Physico-chemical properties: help Change from glycine (G) to medium size and hydrophobic (V)
BLOSUM score: help -3
Variant description: help Does not affect exonuclease activity.
Other resources: help


Sequence information Variant position: help 172
Protein sequence length: help 373
Location on the sequence: help LLIPTLQSEGHIREFPVFGE G EGVLLVGVIDELHYTAKGEL
Residue conservation: help 
Human                         LLIPTL--QSEGHIREFPVFGEG-------------------EGVLLVGVIDELHYTA-------KG-----------------------------EL

Mouse                         AMIPAL--QSEGRVREFPVFGEV------------------

Bovine                        SMIPTL--QSEGRIREFPVFAEV------------------

Zebrafish                     HMIPLL--EAGQRVREFPVFGVQ------------------

Baker's yeast                 NRLVSLFTKGDGHAREIVCHGFINLEDGKLVEHLLNSDSKT

Fission yeast                 EGIMLL--QKNGITREFPIWGYY------------------
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 373 Exonuclease V
Beta strand 161 – 172



Literature citations
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT VAL-172; Human exonuclease 5 is a novel sliding exonuclease required for genome stability.
Sparks J.L.; Kumar R.; Singh M.; Wold M.S.; Pandita T.K.; Burgers P.M.;
J. Biol. Chem. 287:42773-42783(2012)
Cited for: FUNCTION; SUBCELLULAR LOCATION; CATALYTIC ACTIVITY; COFACTOR; INTERACTION WITH THE REPLICATION PROTEIN A (RPA) COMPLEX; MUTAGENESIS OF GLU-196; CYS-343 AND CYS-346; CHARACTERIZATION OF VARIANTS ASN-115 AND VAL-172;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.