UniProtKB/Swiss-Prot Q9H790: Variant p.Gly172Val

Exonuclease V
Gene: EXO5
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Variant information Variant position:

172 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant:

LB/B The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Glycine (G) to Valine (V) at position 172 (G172V, p.Gly172Val). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties:

Change from glycine (G) to medium size and hydrophobic (V) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score:

-3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page
Variant description:

Does not affect exonuclease activity. Any additional useful information about the variant.
Other resources:

Links to websites of interest for the variant.

Variant rs11208299 [ dbSNP | Ensembl ]

Sequence information Variant position:

172 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length:

373 The length of the canonical sequence.
Location on the sequence:

LLIPTLQSEGHIREFPVFGE G EGVLLVGVIDELHYTAKGEL The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         LLIPTL--QSEGHIREFPVFGEG-------------------EGVLLVGVIDELHYTA-------KG-----------------------------EL

Mouse                         AMIPAL--QSEGRVREFPVFGEV------------------

Bovine                        SMIPTL--QSEGRIREFPVFAEV------------------

Zebrafish                     HMIPLL--EAGQRVREFPVFGVQ------------------

Baker's yeast                 NRLVSLFTKGDGHAREIVCHGFINLEDGKLVEHLLNSDSKT

Fission yeast                 EGIMLL--QKNGITREFPIWGYY------------------

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	1 – 373	Exonuclease V
Beta strand	161 – 172

Literature citations
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT VAL-172; Human exonuclease 5 is a novel sliding exonuclease required for genome stability.
Sparks J.L.; Kumar R.; Singh M.; Wold M.S.; Pandita T.K.; Burgers P.M.;
J. Biol. Chem. 287:42773-42783(2012)
Cited for: FUNCTION; SUBCELLULAR LOCATION; CATALYTIC ACTIVITY; COFACTOR; INTERACTION WITH THE REPLICATION PROTEIN A (RPA) COMPLEX; MUTAGENESIS OF GLU-196; CYS-343 AND CYS-346; CHARACTERIZATION OF VARIANTS ASN-115 AND VAL-172;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.