Sequence information
Variant position: 170 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 326 The length of the canonical sequence.
Location on the sequence:
SAVERAWAANGSMGEPVIKC
E FEKVISMEYMVYFNFFVWVL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SAVERAWAANGSMGEPVIKCE FEKVISMEYMVYFNFFVWVL
GEAQRAWAANGSGGEPVIKCE FEKVISMEYMVYFNFFVWVL
Mouse SEVEQAWIANGSVGEPVIKCE FEKVISMEYMVYFNFFVWVL
Rat SVVEQDWRANGSVGEPVIKCE FEKVISMEYMVYFNFFVWVL
Bovine SAVERDWLANGSVGEPVIECQ FEKVISMEYMVYFNFFVWVL
Rabbit REVQRAWAANGSVGEPVIKCE FEKVISMEYMVYFNFFVWVL
Chicken NKVLGTRDLNVSHSEFVIKCQ FETVISMEYMVYFNFFVWVL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 326
Adenosine receptor A1
Topological domain
147 – 176
Extracellular
Glycosylation
159 – 159
N-linked (GlcNAc...) asparagine
Alternative sequence
126 – 326
Missing. In isoform 2.
Literature citations
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Science 314:268-274(2006)
Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-170;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.