Variant position: 725 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 967 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LASVGEYGASPLCLPYAPPE GQPAALGFTVALVMMNSFCFL
Mouse LASVGEYGASPLCLPYAPPE GRPAALGFAVALVMMNSLCFL
Zebrafish LIGVGEYGATPLCMPSPLPD GEPSTLGFMVALIMMNSLCFL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
25 – 967 Leucine-rich repeat-containing G-protein coupled receptor 6
709 – 727 Extracellular
LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.
Gong X.; Carmon K.S.; Lin Q.; Thomas A.; Yi J.; Liu Q.;
PLoS ONE 7:E37137-E37137(2012)
Cited for: FUNCTION; INTERACTION WITH RSPO1; RSPO2 AND RSPO3; SUBCELLULAR LOCATION; CHARACTERIZATION OF VARIANTS CYS-725 AND HIS-928;
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-725 AND HIS-928;
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