Variant position: 1087 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2157 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GGGTGGPNHPPAPRGRTASE TRSEGSEYEEIPKRRRQRGSE
Rhesus macaque GGGTGGPNHPPAPRGRTASE TRSEGSEYEEIPKRRRQRGSE
Mouse GGGSGGTNHPSAPRGRTASE TRSEGSEYEEIPKRRRQRGSE
Rat GGGSGGTNHPSAPRGRTASE TRSEGSEYEEIPKRRRQRGSE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 2157 Protein PRRC2A
41 – 1812 4 X 57 AA type A repeats
740 – 1775 Disordered
1086 – 1123 Basic and acidic residues
1083 – 1083 Phosphothreonine
1085 – 1085 Phosphoserine
1089 – 1089 Phosphoserine
1092 – 1092 Phosphoserine
1094 – 1094 Phosphotyrosine
1106 – 1106 Phosphoserine
834 – 1457 Missing. In isoform 4.
1050 – 1148 RSREFRSYREFRGDDGRGGGTGGPNHPPAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPPPPGAPPSP -> QANSAVTESFEEMMGVEVGQGDQTTLLLPEAAMPARHGARVQSMRKSPSGAGSGAQKQAARPMRVIWLLQTRRLPHPRREHSPRSSRSPTTRSPTLHR. In isoform 2 and isoform 3.
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-1087 AND HIS-1152;
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