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UniProtKB/Swiss-Prot P27708: Variant p.Tyr735Cys

CAD protein
Gene: CAD
Variant information

Variant position:  735
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  US
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Tyrosine (Y) to Cysteine (C) at position 735 (Y735C, p.Tyr735Cys).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and aromatic (Y) to medium size and polar (C)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -2
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In a colorectal cancer sample; somatic mutation.
Any additional useful information about the variant.



Sequence information

Variant position:  735
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  2225
The length of the canonical sequence.

Location on the sequence:   LPELRNSVTGGTAAFEPSVD  Y CVVKIPRWDLSKFLRVSTKI
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         LPELRNSVTGGT-AAFEPSVDYCVVKIPRWDLSKFLRVSTKI

Mouse                         LPELRNSVTGGT-AAFEPSLDYCVVKIPRWDLSKFLRVSTK

Caenorhabditis elegans        LPVIRNSVTGTTTACFEPSLDYCVVKIPRWDLGKFARVSTQ

Drosophila                    LPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKH

Slime mold                    LAALRNTITKKTTACFEPSLDYLVVKMPRWDLKKFTRVSNK

Baker's yeast                 LNEVKNSVTKSTCACFEPSLDYCVVKMPRWDLKKFTRVSTE

Fission yeast                 LNEVKNSVTKVTCACFEPSLDYVVVKIPRWDLKKFTRVSTQ

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 2 – 2225 CAD protein
Region 395 – 1455 CPSase (Carbamoyl-phosphate synthase)
Region 395 – 933 CPSase A
Modified residue 747 – 747 N6-acetyllysine


Literature citations

The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Science 314:268-274(2006)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-177 AND CYS-735;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.