UniProtKB/Swiss-Prot P15336: Variant p.Asp352His

Cyclic AMP-dependent transcription factor ATF-2
Gene: ATF2
Chromosomal location: 2q32
Variant information

Variant position:  352
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Unclassified
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Aspartate (D) to Histidine (H) at position 352 (D352H, p.Asp352His).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and acidic (D) to medium size and polar (H)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In a breast cancer sample; somatic mutation.
Any additional useful information about the variant.



Sequence information

Variant position:  352
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  505
The length of the canonical sequence.

Location on the sequence:   TTPQTQSTSGRRRRAANEDP  D EKRRKFLERNRAAASRCRQK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         TTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCR-----------QK

Mouse                         TTPQTQNTSGRRRRAANEDPDEKRRKFLERNRAAASRCR--

Rat                           TTPQTQNTSGRRRRAANEDPDEKRRKFLERNRAAASRCR--

Chicken                       PTQQTPNTGGRRRRAANEDPDEKRRKFLERNRAAASRCR--

Baker's yeast                 YGFDVAIPSNARRFLPNDE--ELRDSYKYGSNVGGSHYAYL

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 505 Cyclic AMP-dependent transcription factor ATF-2
Domain 352 – 415 bZIP
Modified residue 340 – 340 Phosphoserine; by PKC/PRKCA and PKC/PRKCB
Modified residue 357 – 357 N6-acetyllysine
Modified residue 367 – 367 Phosphoserine; by PKC/PRKCA and PKC/PRKCB
Alternative sequence 34 – 394 Missing. In isoform 6 and isoform 8.
Alternative sequence 210 – 505 Missing. In isoform 3.
Alternative sequence 238 – 505 Missing. In isoform 7.


Literature citations

The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Science 314:268-274(2006)
Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-352;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.