Variant position: 696 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1599 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TTLSTRGPPRGGPGGELPRG PAGLGPRRS-QQGPRKEPRKII
Mouse PALSNRGPPRGGPGGELPRG PAGLGPRRS-QQGPRKETRKI
Rabbit PALSSRGPPRGGPGGELPRG AAGLGPRRSLQPRPPKGARKL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1599 Eukaryotic translation initiation factor 4 gamma 1
565 – 792 MIF4G
682 – 1085 eIF3/EIF4A-binding
685 – 685 Omega-N-methylarginine
694 – 694 Omega-N-methylarginine
696 – 696 P -> PQ. In isoform 7 and isoform 8.
682 – 682 G -> AVWRE. Reduced cleavage by protease 2A from human rhinovirus 2.
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-696;
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