Sequence information
Variant position: 531 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 572 The length of the canonical sequence.
Location on the sequence:
VTVISLLVYKKHKEYNPIEN
S PGNVVRSKGLSVFLNRAKAV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VTVISLLVYKKHKEYNPIENS PGNVVRSKGLSVFLNRAKAV
Mouse VTMVTILLYKKHKAYKPIGNC PRNTVKGKGLSVLLSHAKAP
Rat VTMVTILLYKKHKTYKPIGNC TRNVVKGKGLSVFLSHAKAP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
23 – 572
Transmembrane glycoprotein NMB
Topological domain
520 – 572
Cytoplasmic
Modified residue
542 – 542
Phosphoserine
Literature citations
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Science 314:268-274(2006)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-110 AND ILE-531;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.