Sequence information
Variant position: 481 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 572 The length of the canonical sequence.
Location on the sequence:
VTEGSGRYIPRKPFPDFVYK
R IKARSRLAELRGVPRGLYDG
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VTEGSGRYIPRKPFPDFVYKR IKARSRLAELRGVPRGLYDG
Mouse VTEGSGRYIPRKPFPDFVYKR IKARSRLAELRGVPRGLYDG
Rat VTEGSGRYIPRKPFPDFVYKR IKARSRLAELRGVPRGLYDG
Bovine VTEGSGRYIPRKPFPDFVYKR IKARSRLAELRGVPRGLYDG
Chicken VTEGSGRYIPRKPFPDFVYKR IKARSRLAELRGVPRGLYDG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 572
Dihydropyrimidinase-related protein 2
Modified residue
465 – 465
Phosphoserine
Modified residue
499 – 499
Phosphotyrosine
Helix
476 – 486
Literature citations
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Science 314:268-274(2006)
Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-481;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.