Sequence information
Variant position: 201 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 782 The length of the canonical sequence.
Location on the sequence:
PNEVVVQRLFQVKGRRVVRA
T EVPVSWESFNNGDCFILDLG
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PNEVVVQRLFQVKGRRVVRAT EVPVSWESFNNGDCFILDLG
Mouse PNEVVVQRLFQVKGRRVVRAT EVPVSWDSFNNGDCFILDLG
Rat PNEVVVQRLFQVKGRRVVRAT EVPVSWDSFNNGDCFILDLG
Bovine PNEVVVQRLFQVKGRRVVRAT EVPVSWESFNNGDCFILDLG
Horse PNEVVVQRLLQVKGRRVVRAT EVPVSWESFNNGDCFILDLG
Chicken PNEVTVQRLLQVKGRRTVRAT EVPVSWESFNTGDCFILDLG
Drosophila TNAQGETRLFQVKGKRNVRVR QVNLSVSSMNTGDCFILDAG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Literature citations
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Science 314:268-274(2006)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-22; ILE-201 AND ASN-611;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.