Variant position: 383 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 410 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NAGEELTFDYQMKGSGDISS DSID-HSPAKKRVRTVCKCGAV
Mouse NAGEELTFDYQMKGSGEASS DSID-HSPAKKRVRTQCKCGA
Bovine NAGEELTFDYQMKGSGDVSS DSID-HSPAKKRARTVCKCGA
Chicken KAGEELTFDYQMKGSIDLTS DSADGLSSSRKRIRTVCKCGA
Xenopus tropicalis KAGEELTFDYQMKGSGDFST DSID-MSPAKKRVRIACKCGA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 410 Histone-lysine N-methyltransferase SUV39H2
398 – 398 Zinc 4
400 – 400 Zinc 4
372 – 372 S-adenosyl-L-methionine
399 – 399 S-adenosyl-L-methionine; via amide nitrogen
381 – 381 Phosphoserine
384 – 384 Phosphoserine
388 – 388 Phosphoserine
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-383;
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