Variant position: 130 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 552 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KHVKYCQYAFDLKCDSVCVN PYHYERVVSPGIDLSGLTLQS
Mouse KHVKYCQYAFDLKCDSVCVN PYHYERVVSPGIDLSGLTLQS
Rat KHVKYCQYAFDLKCDSVCVN PYHYERVVSPGIDLSGLTLQS
Pig KHVKYCQYAFDLKCDSVCVN PYHYERVVSPGIDLSGLTLQS
Bovine KHVKYCQYAFDLKCDSVCVN PYHYERVVSPGIDLSGLTLQS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 552 Mothers against decapentaplegic homolog 4
18 – 142 MH1
1 – 322 Mediates interaction with ZBTB7A
115 – 115 Zinc
127 – 127 Zinc
132 – 132 Zinc
113 – 113 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
130 – 132
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-130; ASN-351 AND HIS-361; INVOLVEMENT IN COLORECTAL CANCER;
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