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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Arg273Leu

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 273
Type of variant: help LP/P [Disclaimer]
Residue change: help From Arginine (R) to Leucine (L) at position 273 (R273L, p.Arg273Leu).
Physico-chemical properties: help Change from large size and basic (R) to medium size and hydrophobic (L)
BLOSUM score: help -2
Variant description: help In LFS; germline mutation and in sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 273
Protein sequence length: help 393
Location on the sequence: help TIITLEDSSGNLLGRNSFEV R VCACPGRDRRTEEENLRKKG
Residue conservation: help 
Human                         TIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKG

                              TIITLEDSSGNVLGRNSFEVRVCACPGRDRRTEEENFHKKG

Rhesus macaque                TIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKKG

Mouse                         TIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKE

Rat                           TIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKE

Pig                           TIITLEDASGNLLGRNSFEVRVCACPGRDRRTEEENFLKKG

Bovine                        TIITLEDSCGNLLGRNSFEVRVCACPGRDRRTEEENLRKKG

Rabbit                        TIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKKG

Sheep                         TIITLEDSRGNLLGRSSFEVRVCACPGRDRRTEEENFRKKG

Cat                           TIITLEDSNGKLLGRNSFEVRVCACPGRDRRTEEENFRKKG

Chicken                       TILTLEGPGGQLLGRRCFEVRVCACPGRDRKIEEENFRKRG

Xenopus laevis                TIITLETPQGLLLGRRCFEVRVCACPGRDRRTEEDNYTKKR

Zebrafish                     TIITLETQEGQLLGRRSFEVRVCACPGRDRKTEESNFKKDQ
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 116 – 292 Interaction with AXIN1
Region 256 – 294 Interaction with E4F1
Region 273 – 280 Interaction with DNA
Modified residue 269 – 269 Phosphoserine; by AURKB
Modified residue 284 – 284 Phosphothreonine; by AURKB
Cross 291 – 291 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross 292 – 292 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Mutagenesis 269 – 269 S -> A. Abolishes phosphorylation.
Mutagenesis 269 – 269 S -> E. Inhibits strongly its transcriptional activity.
Mutagenesis 284 – 284 T -> E. Inhibits strongly its transcriptional activity.
Beta strand 264 – 274



Literature citations
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Science 314:268-274(2006)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-134; PHE-157; CYS-163; HIS-175; ARG-177; ARG-193; PRO-213; PHE-241; PHE-242; GLN-248; TRP-248; SER-249; TRP-267; LYS-271; CYS-273; HIS-273; LEU-273; SER-278; ILE-280 AND HIS-281;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.