Variant position: 298 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 553 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WLAESARWLLTTGRLDWGLQ ELWRVAAINGKGAVQDTLTPE
Mouse WLPESARWLITVGKLDQGLQ ELQRVAAVNRRKAEGDTLTME
Rat WLPESARWLITVGRLDQSLR ELQRVAAVNRRKAEADTLTVE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 553 Solute carrier family 22 member 12
Molecular identification of a renal urate anion exchanger that regulates blood urate levels.
Enomoto A.; Kimura H.; Chairoungdua A.; Shigeta Y.; Jutabha P.; Cha S.H.; Hosoyamada M.; Takeda M.; Sekine T.; Igarashi T.; Matsuo H.; Kikuchi Y.; Oda T.; Ichida K.; Hosoya T.; Shimokata K.; Niwa T.; Kanai Y.; Endou H.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; TISSUE SPECIFICITY; SUBCELLULAR LOCATION; VARIANTS RHUC1 MET-217 AND ASP-298; CHARACTERIZATION OF VARIANTS RHUC1 MET-217 AND ASP-298;
Molecular analysis of the SLC22A12 (URAT1) gene in patients with primary gout.
Vazquez-Mellado J.; Jimenez-Vaca A.L.; Cuevas-Covarrubias S.; Alvarado-Romano V.; Pozo-Molina G.; Burgos-Vargas R.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 278-318; VARIANT RHUC1 ASP-298; VARIANTS GLY-284; CYS-290; GLU-297 AND SER-305;
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