Variant position: 84 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 360 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TKAINGKYHRFLGRHFPRFY VLYTIFMKGLQMLWADAKKAR
Mouse TRAINGSYHRFLGRHFPRFY ALYTTFMKGIQMLWADGKKAR
Bovine TKVINGKYHRFLGRHFPRFY VPYTIFMKGLQMLWADGKKAR
Xenopus tropicalis AKYANEKYEHFLERKFPNFY LLYSTFMKGFRMLMTEAKEVG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 360 LETM1 domain-containing protein 1
1 – 137 Cytoplasmic
1 – 110 Required and sufficient for mitochondrial import
1 – 260 Missing. In isoform 5.
1 – 157 Missing. In isoform 4.
Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization.
Ko J.; Lee Y.H.; Hwang S.Y.; Lee Y.S.; Shin S.M.; Hwang J.H.; Kim J.; Kim Y.W.; Jang S.-W.; Ryoo Z.Y.; Kim I.-K.; Namkoong S.E.; Kim J.W.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); VARIANT ILE-84; FUNCTION; TISSUE SPECIFICITY;
4-1BB-mediated inducible gene.
Kang S.W.; Kwon B.S.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 6); VARIANT ILE-84;
The full-ORF clone resource of the German cDNA consortium.
Bechtel S.; Rosenfelder H.; Duda A.; Schmidt C.P.; Ernst U.; Wellenreuther R.; Mehrle A.; Schuster C.; Bahr A.; Bloecker H.; Heubner D.; Hoerlein A.; Michel G.; Wedler H.; Koehrer K.; Ottenwaelder B.; Poustka A.; Wiemann S.; Schupp I.;
BMC Genomics 8:399-399(2007)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-336 (ISOFORM 3); VARIANT ILE-84;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.