Variant position: 389 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 770 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DKDSGDVAALRGSRKFNILG TNTKVMNMEESNNGSLSAEFK
Mouse DKDSGDVAALRGSRKFNILG TNTKVMNMEESNNGSLSAEFK
Rat DKDSGDVAALRGSRKFNILG TNTKVMNMEESNNGSLSAEFK
Pig DKDSGDVAALRGSRKFNILG TNTKVMNMEESNNGSLSAEFK
Bovine DKDSGDVAALRGSRKFNILG TNTKVMNMEESNNGSLSAEFK
Chicken DKDSGDVAALRGSRKFNILG TNTKVMNMEESNNGSLSAEFK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 770 Signal transducer and activator of transcription 3
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
Minegishi Y.; Saito M.; Tsuchiya S.; Tsuge I.; Takada H.; Hara T.; Kawamura N.; Ariga T.; Pasic S.; Stojkovic O.; Metin A.; Karasuyama H.;
Cited for: VARIANTS HIES1 GLN-382; TRP-382; ILE-389; TYR-437 AND VAL-463 DEL; CHARACTERIZATION OF VARIANTS HIES1 GLN-382; TRP-382; ILE-389; TYR-437 AND VAL-463 DEL;
Signal transducer and activator of transcription 3 mutation with invasive eosinophilic disease.
Crosby K.; Swender D.; Chernin L.; Hafez-Khayyata S.; Ochs H.; Tcheurekdjian H.; Hostoffer R.;
Allergy Rhinol. (Providence) 3:E94-E97(2012)
Cited for: VARIANT HIES1 ILE-389;
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