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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P40763: Variant p.Val637Met

Signal transducer and activator of transcription 3
Gene: STAT3
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Variant information Variant position: help 637 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Valine (V) to Methionine (M) at position 637 (V637M, p.Val637Met). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic. The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In HIES1; reduced DNA-binding ability. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 637 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 770 The length of the canonical sequence.
Location on the sequence: help GGVTFTWVEKDISGKTQIQS V EPYTKQQLNNMSFAEIIMGY The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         GGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGY

Mouse                         GGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGY

Rat                           GGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGY

Pig                           GGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGY

Bovine                        GGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGY

Chicken                       GGITFTWVEKDISGKTQIQSVEPYTKQQLNSMSFAEIIMGY
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 770 Signal transducer and activator of transcription 3
Domain 580 – 670 SH2
Modified residue 631 – 631 Allysine; alternate
Modified residue 631 – 631 N6-acetyllysine; alternate
Modified residue 640 – 640 Phosphotyrosine; by TYK2



Literature citations
STAT3 mutations in the hyper-IgE syndrome.
Holland S.M.; DeLeo F.R.; Elloumi H.Z.; Hsu A.P.; Uzel G.; Brodsky N.; Freeman A.F.; Demidowich A.; Davis J.; Turner M.L.; Anderson V.L.; Darnell D.N.; Welch P.A.; Kuhns D.B.; Frucht D.M.; Malech H.L.; Gallin J.I.; Kobayashi S.D.; Whitney A.R.; Voyich J.M.; Musser J.M.; Woellner C.; Schaffer A.A.; Puck J.M.; Grimbacher B.;
N. Engl. J. Med. 357:1608-1619(2007)
Cited for: VARIANTS HIES1 GLN-382; LEU-382; TRP-382; LEU-384; SER-384; GLN-423; VAL-463 DEL; ASN-611; VAL-621; ILE-622; LEU-637; MET-637; GLN-644 DEL AND CYS-657; Functional characterization of two new STAT3 mutations associated with hyper-IgE syndrome in a Mexican cohort.
Alcantara-Montiel J.C.; Staines-Boone T.; Lopez-Herrera G.; Espinosa-Rosales F.; Espinosa-Padilla S.E.; Hernandez-Rivas R.; Santos-Argumedo L.;
Clin. Genet. 89:217-221(2016)
Cited for: VARIANTS HIES1 TRP-382; TYR-395; TYR-425; MET-637 AND CYS-657; CHARACTERIZATION OF VARIANTS HIES1 TRP-382; TYR-395; TYR-425; MET-637 AND CYS-657; PHOSPHORYLATION AT TYR-705 AND SER-727;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.