Variant position: 199 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 317 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SHKVSLSSWYHDRGWAKISN MTFSNGKLIVNQDGFYYLYAN
Mouse SHKVTLSSWYHDRGWAKISN MTLSNGKLRVNQDGFYYLYAN
Rat SHKVSLSSWYHDRGWAKISN MTLSNGKLRVNQDGFYYLYAN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 317 Tumor necrosis factor ligand superfamily member 11, membrane form
140 – 317 Tumor necrosis factor ligand superfamily member 11, soluble form
69 – 317 Extracellular
198 – 198 N-linked (GlcNAc...) asparagine
194 – 202
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.
Sobacchi C.; Frattini A.; Guerrini M.M.; Abinun M.; Pangrazio A.; Susani L.; Bredius R.; Mancini G.; Cant A.; Bishop N.; Grabowski P.; Del Fattore A.; Messina C.; Errigo G.; Coxon F.P.; Scott D.I.; Teti A.; Rogers M.J.; Vezzoni P.; Villa A.; Helfrich M.H.;
Nat. Genet. 39:960-962(2007)
Cited for: VARIANT OPTB2 LYS-199;
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