Variant position: 143 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 441 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FVDIERYPDLPYVYVNSSGT IENYKPIQVVSACSLETYAFP
Mouse FVDVERSPDLPYVYVNSSGT IRNHKPIQVVSACSLQTYAFP
Rat FVDVERSPDLPYVYVNSSGT IRNHKPIQVVSACSLQTYAFP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
22 – 441 5-hydroxytryptamine receptor 3B
22 – 238 Extracellular
138 – 138 N-linked (GlcNAc...) asparagine
138 – 138 N -> S. Reduced molecular weight. Very little expression in the cell membrane.
Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression.
Yamada K.; Hattori E.; Iwayama Y.; Ohnishi T.; Ohba H.; Toyota T.; Takao H.; Minabe Y.; Nakatani N.; Higuchi T.; Detera-Wadleigh S.D.; Yoshikawa T.;
Biol. Psychiatry 60:192-201(2006)
Cited for: VARIANTS SER-129; THR-143 AND ILE-183;
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