Variant position: 188 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 282 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GSPAPLPADALVSAFCLEAV SPDLASFQRALDHITTLLRPG
Mouse PSLVPLPADALVSAFCLEAV SPDLTSFQRALHHITTLLRPG
Rat SGLAPLPADALVSAFCLEAV SPDLPSFRQALYHITTLLRPG
Pig GSLAPLPADALVSAFCLEAV SPDLASFQRALDHITTLLRSG
Bovine GGLAPLPADALVSAFCLEAV SPDLASFQRALDHITTLLRPG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 282 Phenylethanolamine N-methyltransferase
181 – 181 S-adenosyl-L-methionine; via carbonyl oxygen
185 – 185 E -> AQ. Strongly reduced enzyme activity. Increases affinity for S-adenosyl-L-methionine.
185 – 185 E -> D. Strongly reduced enzyme activity. Decreases affinity for substrate and S-adenosyl-L-methionine 3-fold.
No reference for the current variant in UniProtKB/Swiss-Prot.
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