Variant position: 163 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 217 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RLKNIKAAT-NHVTPEEKEQV YRERQKYCKEWRKRKRMATEL
Mouse RLKNIKAAT-NHVTPEEKEKV YRDRQKYCKEWRKRKRMTTE
Rat RLKNIKAAT-NHVTPEEKEKV YRERQKYCKEWRKRKRMTTE
Xenopus laevis KLTNIKSAT-NHVTPAEKEKV YGERKHFCKEWKKRKRMATD
Slime mold KLLTFQTK--EIMSDKDKQRL DDTIKKARSEWVKRKALFRD
Baker's yeast KLQSLQDDW-DPANDEIVKRI MSEDTLLQKEITKRSKICKN
Fission yeast KLESLRNGTVKQISKEAMQKT DKNYDFAKKGFSNRKKMFYD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 217 Homologous-pairing protein 2 homolog
118 – 182 DNA binding
No reference for the current variant in UniProtKB/Swiss-Prot.
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