Variant position: 91 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 551 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VSINGC-GSSCRSGFGGRASN RFGVNSGFGYGGGVGGGFSGP
Mouse VSIGGCAGSGFRGGFGGRTSS GFGGSSGFAYGGGIGGGFGG
Rat VSVGGCAGSGFRSGFGGRASS SF----------GYGGGFGG
Bovine VSISGC-GSNFRSGFGGRASS GFGVSGGFGYGGGIGGGHGG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 551 Keratin, type II cytoskeletal 75
1 – 148 Head
A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle.
Winter H.; Langbein L.; Praetzel S.; Jacobs M.; Rogers M.A.; Leigh I.M.; Tidman N.; Schweizer J.;
J. Invest. Dermatol. 111:955-962(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; TISSUE SPECIFICITY; VARIANTS GLY-91 AND ARG-485;
Characterization of a 300 kbp region of human DNA containing the type II hair keratin.
Rogers M.A.; Winter H.; Langbein L.; Wolf C.; Schweizer J.;
J. Invest. Dermatol. 114:464-472(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS GLY-91 AND ARG-485;
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