Variant position: 161 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 551 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TIQRVRAEEREQIKTLNNKF ASFIDKVRFLEQQNKVLETKW
Mouse TIQRVRKEEREQIKTLNNKF ASFIDKVRFLEQQNKVLETKW
Rat TIQRVRKEEREQIKTLNNKF ASFIDKVRFLEQQNKVLETKW
Bovine NIQRVRKEEREQIKTLNNKF ASFIDKVRFLEQQNKVLETKW
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae.
Winter H.; Schissel D.; Parry D.A.D.; Smith T.A.; Liovic M.; Birgitte Lane E.; Edler L.; Langbein L.; Jave-Suarez L.F.; Rogers M.A.; Wilde J.; Peters G.; Schweizer J.;
J. Invest. Dermatol. 122:652-657(2004)
Cited for: VARIANT THR-161; CHARACTERIZATION OF VARIANT THR-161; ASSOCIATION WITH INCREASED RISK TO DEVELOP PFB;
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