Variant position: 14 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MVLSPADKTNVKA AWGKVGAHAGEYGAEALERMF
Gorilla -VLSPADKTNVKA AWGKVGAHAGDYGAEALERMF
Rhesus macaque MVLSPADKSNVKA AWGKVGGHAGEYGAEALERMF
Chimpanzee MVLSPADKTNVKA AWGKVGAHAGEYGAEALERMF
Mouse MVLSGEDKSNIKA AWGKIGGHGAEYGAEALERMF
Rat MVLSADDKTNIKN CWGKIGGHGGEYGEEALQRMF
Pig -VLSAADKANVKA AWGKVGGQAGAHGAEALERMF
Bovine MVLSAADKGNVKA AWGKVGGHAAEYGAEALERMF
Rabbit MVLSPADKTNIKT AWEKIGSHGGEYGAEAVERMF
Sheep MVLSAADKSNVKA AWGKVGGNAGAYGAEALERMF
Cat -VLSAADKSNVKA CWGKIGSHAGEYGAEALERTF
Horse MVLSAADKTNVKA AWSKVGGHAGEYGAEALERMF
Chicken MVLSAADKNNVKG IFTKIAGHAEEYGAETLERMF
Xenopus tropicalis MHLTADDKKHIKA IWPSVAAHGDKYGGEALHRMF
Zebrafish MSLSDTDKAVVKA IWAKISPKADEIGAEALARML
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1 Removed
2 – 142 Hemoglobin subunit alpha
12 – 12 Not glycated
14 – 15 (Microbial infection) Cleavage; by N.americanus apr-2
4 – 4 Phosphoserine
8 – 8 N6-succinyllysine; alternate
9 – 9 Phosphothreonine
12 – 12 N6-succinyllysine
17 – 17 N6-acetyllysine; alternate
17 – 17 N6-succinyllysine; alternate
25 – 25 Phosphotyrosine
8 – 8 N-linked (Glc) (glycation) lysine; alternate
17 – 17 N-linked (Glc) (glycation) lysine; alternate
5 – 18
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.