UniProtKB/SwissProt variant VAR

Nodal homolog
Gene: NODAL
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Variant information Variant position:

165
Type of variant:

LB/B
Residue change:

From Histidine (H) to Arginine (R) at position 165 (H165R, p.His165Arg).
Physico-chemical properties:

Change from medium size and polar (H) to large size and basic (R)
BLOSUM score:

0
Other resources:

Variant rs1904589 [ dbSNP | Ensembl ]

Sequence information Variant position:

165
Protein sequence length:

347
Location on the sequence:

TFSLGSMVLEVTRPLSKWLK H PGALEKQMSRVAGECWPRPP
Residue conservation:

Human                         TFSLGSMVLEVTRPLSKWLKHPGALEKQMSRVAGEC----------------------WPRPP

Mouse                         TFASGSTVLEVTKPLSKWLKDPRALEKQVSSRAEKC-----

Xenopus laevis                TKGSPWKVFNVTKILQPYFKERRDIDSEHLKAKERAERGSG

Xenopus tropicalis            TKGSPWKVFNVTRILQHYFKEGQDIKSEYLRTKDRAERGSG

Sequence annotation in neighborhood:

Type	Positions	Description
Propeptide	27 – 237

Literature citations
Human Nodal-related gene.
Tate Genshu T.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT ARG-165;

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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q96S42: Variant p.His165Arg