Sequence information
Variant position: 22 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 954 The length of the canonical sequence.
Location on the sequence:
SLPLTEEQRKKIEENRQKAL
A RRAEKLLAEQHQRTSSGTSI
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SLPLTEEQRKKIEENRQKALA RRAEKLLAEQH-QRTSSGTSI
Mouse SLPLTEEQRKKIEENRQKALA RRAEKL-SEQP-QSAASGSS
Rat SLPLTEEQRKKIEENRQKALA RRAEKLWAEQP-QSTASGSS
Bovine CPCLLQRSRGKIEANRQKALA RRAEKLLAEQH-QK------
Xenopus laevis SVCLTEEQKRKIEENRQRALA RRAERLAAQQNTLKQTNNSH
Xenopus tropicalis SVCLTEEQKRKIEENRQRALA RRAERLAAQQN--SQTNRSL
Zebrafish SVSLTPEQQRRIEENRKKALA RRAERQAQIAD---------
Caenorhabditis elegans V--LTDEQRQAIAKKREEAIR RAAAYREREM----------
Drosophila STCSSSE----IAEKKRIALA KLQAKKSQLLA---------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 954
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
Region
2 – 30
Mediates interaction with RPA2
Coiled coil
3 – 34
Modified residue
2 – 2
N-acetylserine
Helix
7 – 29
Literature citations
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS GLY-22 AND GLN-377;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.