Sequence information
Variant position: 186 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 777 The length of the canonical sequence.
Location on the sequence:
QPAIKKDASAQQDSYEFVSP
S PPADVSERAKKASARSGKKQ
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QPAIKKDASAQQDS-YEFVSPS PPADVSERAKKASARSGKKQ
Mouse QPQKAKDDKAQEASMYEFVSAT PPVAVPKSAKTASRTSAKK
Rat QPQKAKDDKAQEASVFEFVSAT PPVVVSTRAKTASRTSAKK
Caenorhabditis elegans DDLMCKDENRENSN-------S PELDIFHDYSKEASPTRNS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 777
BRCA1-associated RING domain protein 1
Modified residue
186 – 186
Phosphoserine
Cross
170 – 170
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Alternative sequence
128 – 777
Missing. In isoform gamma.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.