Variant position: 1255 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1261 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VNPMCQRPRLKRMQQFEDLE GEIPQFV
Mouse GTPTCQRPRLKRMQQFEDLE DEIPQFV
Rat GTPTCQRPRLKRMQQFEDLE DEIPQFV
Bovine VPTACQRPRLKRMQQFEDLE DEIPQFV
Zebrafish AKPLYQR-RSRRMQELEHRE ---AHFV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1261 Rho GTPase-activating protein 29
394 – 1261 Missing. In isoform 2.
A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1.
Saras J.; Franzen P.; Aspenstroem P.; Hellman U.; Gonez L.J.; Heldin C.-H.;
J. Biol. Chem. 272:24333-24338(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); PROTEIN SEQUENCE OF 64-72; 221-228; 349-357; 456-468; 666-678; 943-946; 971-985; 1015-1024; 1069-1079 AND 1212-1224; FUNCTION; TISSUE SPECIFICITY; INTERACTION WITH PTPN13; VARIANT ASP-1255;
Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.; Ohara O.; Nagase T.; Kikuno R.F.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-1261 (ISOFORM 1); VARIANT ASP-1255;
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