UniProtKB/SwissProt variant VAR

Variant information

Variant position:

136

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:

LB/B

The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Arginine (R) to Serine (S) at position 136 (R136S, p.Arg136Ser).

Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:

Change from large size and basic (R) to small size and polar (S)

The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:

-1

The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page

Other resources:

Links to websites of interest for the variant.

Variant rs8178747 [ dbSNP | Ensembl ]

Sequence information

Variant position:

136

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:

562

The length of the canonical sequence.

Location on the sequence:

GKCCEIDTRATCYEDQGISY R GTWSTAESGAECTNWNSSAL

The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         GKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSAL

Mouse                         GKRCDIDTRATCFEEQGITYRGTWSTAESGAECINWNSSVL

Rat                           GKRCDIDTRATCFEGQGITYRGTWSTAENGAECINWNSSAL

Pig                           GRQCEIDARATCYEDQGITYRGTWSTTESGAECVNWNTSGL

Bovine                        GKLCEIDATATCYKDQGVAYRGTWSTAESGAECANWNSSGL

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	36 – 562	Tissue-type plasminogen activator
Chain	36 – 310	Tissue-type plasminogen activator chain A
Domain	127 – 208	Kringle 1
Glycosylation	152 – 152	N-linked (GlcNAc...) asparagine
Disulfide bond	127 – 208
Alternative sequence	79 – 208	Missing. In isoform 4.

Literature citations

Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ASP-34; SER-136; THR-146 AND TRP-164;

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P00750: Variant p.Arg136Ser