Sequence information
Variant position: 136 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 562 The length of the canonical sequence.
Location on the sequence:
GKCCEIDTRATCYEDQGISY
R GTWSTAESGAECTNWNSSAL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GKCCEIDTRATCYEDQGISYR GTWSTAESGAECTNWNSSAL
Mouse GKRCDIDTRATCFEEQGITYR GTWSTAESGAECINWNSSVL
Rat GKRCDIDTRATCFEGQGITYR GTWSTAENGAECINWNSSAL
Pig GRQCEIDARATCYEDQGITYR GTWSTTESGAECVNWNTSGL
Bovine GKLCEIDATATCYKDQGVAYR GTWSTAESGAECANWNSSGL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
36 – 562
Tissue-type plasminogen activator
Chain
36 – 310
Tissue-type plasminogen activator chain A
Domain
127 – 208
Kringle 1
Glycosylation
152 – 152
N-linked (GlcNAc...) asparagine
Disulfide bond
127 – 208
Alternative sequence
79 – 208
Missing. In isoform 4.
Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ASP-34; SER-136; THR-146 AND TRP-164;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.