Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P00750: Variant p.Ala146Thr

Tissue-type plasminogen activator
Gene: PLAT
Feedback?
Variant information Variant position: help 146
Type of variant: help LB/B
Residue change: help From Alanine (A) to Threonine (T) at position 146 (A146T, p.Ala146Thr).
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and polar (T)
BLOSUM score: help 0
Other resources: help


Sequence information Variant position: help 146
Protein sequence length: help 562
Location on the sequence: help TCYEDQGISYRGTWSTAESG A ECTNWNSSALAQKPYSGRRP
Residue conservation: help 
Human                         TCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRP

Mouse                         TCFEEQGITYRGTWSTAESGAECINWNSSVLSLKPYNARRP

Rat                           TCFEGQGITYRGTWSTAENGAECINWNSSALSQKPYSARRP

Pig                           TCYEDQGITYRGTWSTTESGAECVNWNTSGLASMPYNGRRP

Bovine                        TCYKDQGVAYRGTWSTAESGAECANWNSSGLAMKPYSGRRP
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 36 – 562 Tissue-type plasminogen activator
Chain 36 – 310 Tissue-type plasminogen activator chain A
Domain 127 – 208 Kringle 1
Glycosylation 152 – 152 N-linked (GlcNAc...) asparagine
Disulfide bond 127 – 208
Alternative sequence 79 – 208 Missing. In isoform 4.



Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ASP-34; SER-136; THR-146 AND TRP-164;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.