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UniProtKB/Swiss-Prot Q7L3B6: Variant p.Ser291Phe

Hsp90 co-chaperone Cdc37-like 1
Gene: CDC37L1
Variant information

Variant position:  291
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Serine (S) to Phenylalanine (F) at position 291 (S291F, p.Ser291Phe).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from small size and polar (S) to large size and aromatic (F)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -2
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  291
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  337
The length of the canonical sequence.

Location on the sequence:   RLYSQSQSFQPMTVQNHVPH  S GVGSIGLLESLPQNPDYLQY
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         RLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLPQNPDYLQY

Mouse                         RLYAQSQSLQPVTVQNHVPHSGVGCIGSLESLPQNPDSLQC

Rat                           RLYAQSQSFAPVTVENHAPHSGVGCIGSAEPLPQNPDSLQC

Bovine                        RLYSQSPNFQPVTVQNHVPHSGVGSIGLLESLPQNPDYLQY

Xenopus tropicalis            RQHAECQRYEAAILRKPAFPPDLGHMGTQQCHQK--DVLQS

Zebrafish                     KEYTMKSTGETPKDTVHQNTPPACCLDPKEVFESLPQELKT

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 337 Hsp90 co-chaperone Cdc37-like 1
Region 267 – 337 Interaction with Hsp70
Region 278 – 337 Required for interaction with STIP1


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.