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UniProtKB/Swiss-Prot Q7L3B6: Variant p.Ser291Phe

Hsp90 co-chaperone Cdc37-like 1
Gene: CDC37L1
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Variant information Variant position: help 291
Type of variant: help LB/B
Residue change: help From Serine (S) to Phenylalanine (F) at position 291 (S291F, p.Ser291Phe).
Physico-chemical properties: help Change from small size and polar (S) to large size and aromatic (F)
BLOSUM score: help -2
Other resources: help


Sequence information Variant position: help 291
Protein sequence length: help 337
Location on the sequence: help RLYSQSQSFQPMTVQNHVPH S GVGSIGLLESLPQNPDYLQY
Residue conservation: help 
Human                         RLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLPQNPDYLQY

Mouse                         RLYAQSQSLQPVTVQNHVPHSGVGCIGSLESLPQNPDSLQC

Rat                           RLYAQSQSFAPVTVENHAPHSGVGCIGSAEPLPQNPDSLQC

Bovine                        RLYSQSPNFQPVTVQNHVPHSGVGSIGLLESLPQNPDYLQY

Xenopus tropicalis            RQHAECQRYEAAILRKPAFPPDLGHMGTQQCHQK--DVLQS

Zebrafish                     KEYTMKSTGETPKDTVHQNTPPACCLDPKEVFESLPQELKT
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 337 Hsp90 co-chaperone Cdc37-like 1
Region 267 – 337 Interaction with Hsp70
Region 278 – 337 Required for interaction with STIP1



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.