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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q14164: Variant p.Ile543Met

Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Gene: IKBKE
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Variant information Variant position: help 543
Type of variant: help LB/B
Residue change: help From Isoleucine (I) to Methionine (M) at position 543 (I543M, p.Ile543Met).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 543
Protein sequence length: help 716
Location on the sequence: help LNRELVKSRDQVHEDRSIQQ I QCCLDKMNFIYKQFKKSRMR
Residue conservation: help 
Human                         LNRELVKSRDQVHED-RSIQQIQCCLDKMNFIYKQFKKSRMR

Mouse                         LGEELLKNRDQIHEDNKSIQKIQCCLDKMHFIYKQFKKSRM
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 716 Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Region 383 – 647 Interaction with DDX3X



Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS LYS-128; THR-371; ASP-515; MET-543; VAL-602 AND LEU-713;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.