Sequence information
Variant position: 616 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 678 The length of the canonical sequence.
Location on the sequence:
QSEVSAAQLQERLAVLERHL
R SPVLTFAGGLPDVPVTSAPV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QSEVSAAQLQERLAVLERHLR SPVLTFAGGLPDVPVTSAPV
Mouse QSEVSTAQLQERLDTLKTHLQ GSVHTYVGGLPEVSVISAPV
Rat QSEVSTAQLQERLDLLKTRLQ GSVLTFVGGLPDVQVTSTPV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
31 – 678
Growth arrest-specific protein 6
Domain
477 – 670
Laminin G-like 2
Modified residue
621 – 621
Phosphothreonine
Mutagenesis
620 – 620
L -> A. Reduces affinity for AXL 15-fold and decreases activation of AXL.
Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS LEU-41; TYR-231; MET-347; ARG-500; LEU-580; LYS-612 AND GLN-616;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.